(Traduction du texte original par Fabien Piasco)
Des preuves scientifiques indiquent que la vitamine D réduit les infections et les décès.
À tous les gouvernements, responsables de la santé publique, médecins et travailleurs de la santé,
La recherche montre que de faibles niveaux de vitamine D favorisent les infections, les hospitalisations et les décès par COVID-19. Compte tenu de son innocuité, nous appelons à une augmentation des apports en vitamine D.
La vitamine D module des milliers de gènes et de nombreux aspects de la fonction immunitaire, à la fois innée et adaptative. Les preuves scientifiques [1] montrent que :
- Des taux sanguins plus élevés de vitamine D sont associés à des taux inférieurs d’infection par le SRAS-CoV-2.
- Des niveaux de D plus élevés sont associés à un risque plus faible de cas grave (hospitalisation, soins intensifs ou décès).
- Les études d’intervention (y compris les essais cliniques contrôlés randomisés) indiquent que la vitamine D peut être un traitement très efficace.
- De nombreux articles révèlent plusieurs mécanismes biologiques par lesquels la vitamine D influence le COVID-19.
La modélisation de l’inférence causale, les critères de Hill, les études d’intervention et les mécanismes biologiques indiquent que l’impact de la vitamine D sur le COVID-19 est très probablement causale, et pas seulement une corrélation.
La vitamine D est bien connue pour être essentielle, mais la plupart des individus n’en consomment pas assez. Deux définitions courantes de l’insuffisance sont une carence <20 ng / ml (50 nmol / L), cible de la plupart des organisations gouvernementales, et une insuffisance <30 ng / ml (75 nmol / L), la cible de plusieurs sociétés médicales et experts [2].
Trop de gens ont des niveaux inférieurs à ces objectifs. Les taux de carence en vitamine D (<20 ng / ml) dépassent 33% de la population dans la plupart des pays du monde, et la plupart des estimations d’insuffisance (<30 ng / ml) sont bien supérieures à 50% (mais beaucoup plus élevées dans de nombreux pays). [3] Les taux sont encore plus perturbés en hiver, et plusieurs groupes présentent une carence nettement plus importante : les personnes en surpoids, celles à peau foncée (surtout loin de l’équateur) et les résidents des maisons de soins. Ces mêmes groupes font face à un risque accru de COVID-19.
Il a été démontré que 3875 UI (97 mcg) par jour sont nécessaires pour 97,5% des personnes pour atteindre 20 ng / ml, et 6200 UI (155 mcg) pour 30 ng / ml [4], apports bien au-dessus de toutes les directives nationales. Malheureusement, le rapport qui a établi le RDA américain a inclus une erreur statistique admise dans laquelle l’apport requis a été calculé comme étant environ 10 fois trop faible [4].
Maintenant, de nombreux articles indiquent qu’un faible statut en vitamine D affecte le COVID-19 plus fortement que la plupart des autres problèmes de santé, avec un risque accru à des niveaux <30ng / ml (75nmol / L) et un risque sévèrement plus élevé <20ng / ml (50nmol / L) [1].
Les preuves à ce jour suggèrent la possibilité que la pandémie de COVID-19 se maintienne en grande partie par l’infection de ceux qui ont un faible taux de vitamine D, et que les décès sont principalement concentrés chez ceux qui souffrent de cette carence. La simple possibilité qu’il en soit ainsi devrait obliger à rassembler d’urgence davantage de données sur la vitamine D. Même sans plus de données, la prépondérance des preuves indique qu’une augmentation de la vitamine D aiderait à réduire les infections, les hospitalisations, les admissions aux unités de soins intensifs et les décès.
Des décennies de données de sécurité montrent que la vitamine D présente un risque très faible : la toxicité serait extrêmement rare avec les recommandations présentées ici. Le risque de niveaux insuffisants l’emporte de loin sur tout risque lié à des niveaux qui semblent fournir la majeure partie de la protection contre le COVID-19, et ceci est particulièrement différent des médicaments et des vaccins. La vitamine D est beaucoup plus sûre que les corticoïdes, tels que la dexaméthasone, le traitement le plus largement accepté pour avoir également démontré un grand avantage du COVID-19. La sécurité de la vitamine D ressemble plus à celle des masques faciaux. Il n’est pas nécessaire d’attendre d’autres essais cliniques pour augmenter l’utilisation de quelque chose d’aussi sûr, en particulier lorsque remédier à beaucoup de carences ou d’insuffisances devrait déjà être une priorité.
Par conséquent, nous appelons tous les gouvernements, médecins et professionnels de la santé du monde entier à recommander et à mettre en œuvre immédiatement des efforts adaptés à leurs populations adultes, pour augmenter la vitamine D, au moins jusqu’à la fin de la pandémie. Plus précisément pour :
- Recommander des quantités de toutes les sources suffisantes pour atteindre des taux sériques de 25(OH)D supérieurs à 30 ng / ml (75 nmol / L) , un minimum largement approuvé avec des preuves d’un risque réduit de COVID-19.
- Recommander aux adultes un apport en vitamine D de 4000 UI (100 mcg) par jour (ou au moins 2000 UI) en l’absence de test. 4000 UI sont largement considérés comme sûrs. [5]
- Recommander que les adultes présentant un risque accru de carence en raison d’un excès de poids, d’une peau foncée ou vivant dans des maisons de soins puissent avoir besoin d’un apport plus élevé (par exemple 2 fois plus). Les tests peuvent aider à éviter des niveaux trop bas ou trop élevés.
- Recommander aux adultes qui ne reçoivent pas déjà les quantités ci-dessus de recevoir 10 000 UI (250 mcg) par jour pendant 2-3 semaines (ou jusqu’à atteindre 30 ng / ml en cas de test), suivi de la quantité quotidienne ci-dessus. Cette pratique est largement considérée comme sûre. Le corps peut synthétiser plus que cela à partir de la lumière du soleil dans les bonnes conditions (par exemple, une journée d’été à la plage). En outre, le NAM (États-Unis) et l’EFSA (Europe) le qualifient tous deux de «niveau sans effet indésirable observé», même en tant qu’apport d’entretien quotidien.
- Mesurer les taux de 25(OH)D de tous les patients hospitalisés COVID-19 et traiter avec du calcifediol ou de la D3, pour au moins remédier à une insuffisance <30 ng / ml (75 nmol / L), éventuellement avec un protocole du type de Castillo et al. ou Rastogi et al, jusqu’à ce que des preuves soutiennent un meilleur protocole.
- De nombreux facteurs sont connus pour prédisposer les individus à un risque plus élevé d’exposition au SRAS-CoV-2, tels que l’âge, le fait d’être un homme, les comorbidités, etc., mais une vitamine D inadéquate est de loin le facteur de risque modifiable le plus facilement et le plus rapidement avec de nombreuses preuves.
- La vitamine D est peu coûteuse et présente un risque négligeable par rapport au risque considérable de COVID-19.
Veuillez agir immédiatement
Les signataires ci-dessous approuvent cette lettre. Les affiliations n’impliquent pas l’approbation de la lettre par les institutions elles-mêmes.
Cette lettre ne prend aucune position sur d’autres mesures de santé publique en dehors de la vitamine D. Les opinions personnelles des signataires individuels sur toute autre question ne représentent pas le groupe dans son ensemble.
Tous les signataires ne déclarent aucun conflit d’intérêts, sauf indication contraire.
A souligner : Les signataires organisateurs n’ont aucun conflit d’intérêts dans ce domaine (financier ou autre, ni n’ont fait de recherche dans ce domaine avant 2020.
| Signataires (172) | Apport recommandé | Apport journalier personnel |
| Dr. Karl Pfleger, PhD AI & Computer Science, Stanford. Former Google Data Scientist. Biotechnology Investor, AgingBiotech.info, San Francisco, CA, USA. (organizing signatory) | 4000 IU | 7000 IU |
| Dr. Gareth Davies, PhD Medical Physics, Imperial College, London, UK. Codex World’s Top 50 Innovator 2019. Independent Researcher. Lead author of “Evidence Supports a Causal Role for Vitamin D Status in COVID-19 Outcomes.” (organizing signatory) | 4000 IU | 10,000 IU |
| Dr. Bruce W Hollis, PhD. Professor of Pediatrics, Medical University of South Carolina, USA. | 4000 IU | 6000 IU |
| Dr. Barbara J Boucher, MD, FRCP (London). Honorary Professor (Medicine), Blizard Institute, Bart’s & The London School of Medicine and Dentistry, Queen Mary University of London, UK. (significantly contributing signatory) | 4000 IU | 2000 IU |
| Dr. Ashley Grossman, MD FRCP FMedSci. Emeritus Professor of Endocrinology, University of Oxford, UK. Professor of Neuroendocrinology, Barts and the London School of Medicine. 2020 Endocrine Society Laureate Award. | 2000 IU | 2200 IU |
| Dr. Gerry Schwalfenberg, MD, CCFP, FCFP. Assistant Clinical Professor in Family Medicine, University of Alberta, Canada. | 4000 IU | 5000 IU |
| Dr. Giovanna Muscogiuri, MD PhD. Associate Editor, European Journal of Clinical Nutrition. Department of Clinical Medicine and Surgery, Section of Endocrinology, University « Federico II » of Naples, Naples, Italy.. | 4000 IU | 1000 IU |
| Dr. Michael F. Holick, PhD MD. Professor Medicine, Physiology and Biophysics and Molecular Medicine, Director Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, USA. (6000 IU) Disclosure: Consultant Biogena and speaker’s Bureau Abbott Inc. | 4000 IU | 6000 IU |
| Dr. John Umhau, MD, MPH. CDR, USPHS (ret). President, Academy of Medicine of Washington, DC, USA. Ex-NIH: co-author of the first peer-reviewed report linking vitamin D deficiency with acute respiratory infection. (significantly contributing signatory) | 4000 IU | 5000 IU |
| Dr. Pawel Pludowski, MD, dr hab. Associate Professor, Biochemistry, Radioimmunology and Experimental Medicine, Children’s Memorial Health Institute, Warsaw, Poland. Chair, European Vitamin D Association (EVIDAS) [non-profit]. | 4000 IU | 2000 IU |
| Dr. Cedric F. Garland, DrPH. Professor Emeritus, Department of Family Medicine and Public Health, University of California, San Diego, USA. | 4000 IU | 6000 IU |
| Dr. Jose M. Benlloch, Professor, Director of the Institute for Instrumentation on Molecular Imaging, CSIC-UPV, Valencia, Spain. | 2000 IU | 3000 IU |
| Dr. Samantha Kimball, PhD, MLT. Professor, St. Mary’s University, Calgary, Alberta, Canada. Research Director, GrassrootsHealth Nutrient Research Institute [non-profit]. (significantly contributing signatory) | 4000 IU | 6000 IU |
| Dr. William B. Grant, PhD Physics, U. of California, Berkeley. Director at Sunlight, Nutrition, and Health Research Center [non-profit], San Francisco, CA, USA. Disclosure: Receives funding from Bio-Tech Pharmacal, Inc. | 4000 IU | 5300 IU |
| Dr. Carol L. Wagner, MD. Professor, Medical University of South Carolina, USA. | 4000 IU | 5000 IU |
| Dr. Paul Marik, MD, FCCP, FCCM. Chief of Pulmonary and Critical Care Medicine and Professor of Medicine, Eastern Virginia Medical School, Norfolk, VA, USA. | 2000 IU | 2000 IU |
| Dr. Morry Silberstein, MD. Associate Professor, Curtin University, Australia. | 4000 IU | |
| Dr. Vatsal Thakkar, MD. Founder, Reimbursify, NY, USA. Former faculty, NYU and Vanderbilt. Op-Ed writer on Vitamin D and COVID-19. (significantly contributing signatory) | 4000 IU | 10,000 IU |
| Dr. Peter H Cobbold, PhD. Emeritus Professor, Cell Biology, University of Liverpool, UK. | 4000 IU | 4000 IU |
| Dr. Afrozul Haq, PhD. Professor Dept of Food Technology, Jamia Hamdard University, New Delhi, India. | 4000 IU | 2000 IU |
| Dr. Barry H. Thompson, MD, FAAP, FACMG. Clinical Associate Professor (Pediatrics), Uniformed Services University of the Health Sciences, Bethesda, MD, USA. | 4000 IU | 5000 IU |
| Dr. Reinhold Vieth, PhD, FCACB. Professor, Departments of Nutritional Sciences and Laboratory Medicine & Pathobiology, University of Toronto, Canada. Director (retired), Bone and Mineral Group Laboratory, Mt Sinai Hospital. Disclosure: Receives patent royalties from Ddrops (an infant vitamin D supplement). | 4000 IU | 4000 IU |
| Dr. Linda Benskin, PhD, RN, SRN(Ghana), CWCN, CWS, DAPWCA. Independent Researcher for Tropical Developing Countries and Ferris Mfg. Corp, Texas, USA. (significantly contributing signatory) | 4000 IU | 4000 IU |
| Jim O’Neill, CEO, SENS Research Foundation. Former principal associate deputy secretary of Health and Human Services, USA. | 4000 IU | 6000 IU |
| Dr. Eric Feigl-Ding, PhD. Epidemiologist & Health Economist. Senior Fellow, Federation of American Scientists. USA. | 4000 IU | 5000 IU |
| Rt Hon David Davis MP, Member of Parliament (Conservative Party). BSc, Joint Hons Molecular Science / Computer Science, Warwick University, UK. | 4000 IU | 6000 IU |
| Dr. Rupa Huq MP, Member of Parliament (Labour Party). PhD, Cultural Studies, University of East London, UK. | 4000 IU | |
| Dr. Susan J Whiting, PhD. Professor Emerita, University of Saskatchewan, Canada. | 4000 IU | 4000 IU |
| Dr. Richard Mazess. PhD. Emeritus Professor, University of Wisconsin, Madison, USA. | 4000 IU | 5000 IU |
| Dr. Helga Rhein, MD (retired). Sighthill Health Centre, Edinburgh, UK. (significantly contributing signatory) | 4000 IU | 3500 IU |
| Dr. Andrea Doeschl-Wilson, PhD. Professor of Infectious disease genetics and modelling, The Roslin Institute, University of Edinburgh, UK. | 2000 IU | |
| Dr. Ute-Christiane Meier, Dr med habil, PhD (Oxon), Dipl-Biol. Visiting lecturer, Institute of Psychiatry, Psychology & Neuroscience, King’s College, London, UK and Privatdozentin, Ludwig Maximilian University of Munich, Germany. Disclosure: Patent 20160131666: « Biomarkers for inflammatory response. » | 4000 IU | 2500 IU |
| Dr. Luigi Gennari, MD PhD. Full Professor, Internal Medicine, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy. | 4000 IU | 3500 IU |
| Dr. Ased Ali, MBChB, PhD, FRCS. Consultant Urological Surgeon, Mid Yorkshire Hospitals NHS Trust, UK. | 4000 IU | 8000 IU |
| Dr. Pavel Kocovsky, PhD DSc FRSE FRSC. Professor Charles University, Prague, and Czech Academy of Sciences, Czech Republic. | 4000 IU | 6000 IU |
| Dr. Ace Lipson, MD. Endocrinologist. Clinical Professor, George Washington University, Washington, DC, USA. | 4000 IU | 2000 IU |
| Dr. Attila R Garami, MD, PhD Multidisciplinary Medical Sciences. Senior Biomarker Consultant, Switzerland. | 4000 IU | 2500 IU |
| Dr. David S Grimes, MD (retired), FRCP, University of Manchester, UK. | 4000 IU | 4000 IU |
| Dr. Larry Callahan, PhD. Chemist, FDA, Maryland, USA. | 2000 IU | 3000 IU |
| Dr. Jeanne M Marconi, MD, Pediatrics. Vice President of PM Pediatrics, New York, USA. | 4000 IU | 5000 IU |
| Dr. Spiros Karras, MD. Endocrinologist, Department of Endocrinology and Metabolism-Diabetes Center, 1st Department of Internal Medicine, AHEPA University Hospital, Thessaloniki, Greece. | 2000 IU | 2000 IU |
| Dr. Joanna Byers, MBChB, University of Birmingham, UK. | 4000 IU | 5000 IU |
| Dr. Jaimin Bhatt, MBChB, MMed(Surgery) FRCS(Urol) FEBU. Consultant Urological Surgeon, Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde, UK. (2000 IU) | 4000 IU | 2000 IU |
| Dr. Christiane Northrup, MD. Obstetrician/Gynecologist. | 4000 IU | 7500 IU |
| Dr. Jörg Spitz, Dr med. Academy of Human Medicine, Schlangenbad, Germany. | 4000 IU | 10,000 IU |
| Dr. Naghmeh Mirhosseini, MD, PhD, MPH. Research Associate, School of Public Health, University of Saskatchewan, Canada.. | 4000 IU | 5000 IU |
| Dr. Iacopo Chiodini, Associate Professor of Endocrinology, Dept. of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy. Head, Unit for Bone Metabolism Diseases and Diabetes, Istituto Auxologico Italiano, IRCCS, Milan, Italy. | 4000 IU | 3500 IU |
| Dr. David C Anderson, MD MSc FRCP FRCPE FRCPath. Retired Physician and Endocrinologist, Former Professor of Endocrinology, Manchester University, UK and Professor of Medicine, The Chinese University of Hong Kong. | 4000 IU | 4000 IU |
| Dr. Colin Bannon, MBChB. GP (retired), Devon, UK. | 4000 IU | 5000 IU |
| Dr. Patricia S. Latham, MD EdD. Professor of Pathology & Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, USA. | 2000 IU | 2000 IU |
| Dr. Teresa Fuller, MD PhD. Pediatrician, Owings Mills, MD, USA. | 4000 IU | 5000 IU |
| Dr. Omar Wasow, PhD, Harvard. Assistant Professor, Politics, Princeton University, NJ, USA. | 4000 IU | 4000 IU |
| Dr. Fabio Vescini, MD PhD. Endocrinology and Metabolism Unit, University-Hospital S. Maria della Misericordia, Italy. | 2000 IU | 2000 IU |
| Dr. Emily Grossman, PhD Molecular Biology, University of Manchester, UK. Science Author, Broadcaster and Educator. | 4000 IU | 4000 IU |
| Dr. David Carman, MBChB, University of Cape Town, South Africa. | 4000 IU | 3000 IU |
| Dr. Kalliopi Kotsa, Professor, Endocrinology-Diabetes, Dept of Medicine, Aristotle University, Thessaloniki, Greece. | 4000 IU | 4000 IU |
| Dr. Eva Kocovska, PhD, Queen Mary University of London. Gillberg Neuropsychiatry Centre, University of Gothenburg, Sweden. Medical College, Prague, Czech Republic. | 2000 IU | 2000 IU |
| Dr. Benjamin Jacobs, MBBS MD MRCP(UK) FRCPCH. Royal National Orthopaedic Hospital, UK. | 2000 IU | 2000 IU |
| Dr. Joan Lappe, PhD RN FAAN. Professor, Creighton University, Omaha, Nebraska, USA. | 4000 IU | |
| Dr. Ronald A. Primas, MD FACP FACPM DABIHM CTH. New York, NY, USA. | 4000 IU | 4000 IU |
| Dr. Cristina Eller Vainicher, MD. Unit of Endocrinology, Fondazione Ca’Granda IRCCS OSpedale Maggiore Policlinico Milan, Italy. Head of the outpatients clinic for osteoporosis. | 4000 IU | 3500 IU |
| Dr. Matthias Gauger, MD. General Practitioner, Switzerland. | 2000 IU | 3000 IU |
| Dr. David Warwick, DDS. Dentist, Alberta, Canada. Published Researcher. | 4000 IU | 8000 IU |
| Dr. Sunil J. Wimalawansa, MD PhD MBA FRCP FRCPath FACE FACP DSc. Professor of Medicine, Endocrinology & Nutrition, Cardiometabolic & Endocrine Institute, New Jersey, USA. | 4000 IU | 5000 IU |
| Perry S. Holman. Executive Director, Vitamin D Society [non-profit], Canada. | 4000 IU | 4000 IU |
| Sharon McDonnell, MPH. Biostatistician, GrassrootsHealth Nutrient Research Institute [non-profit], Encinitas, CA, USA. | 4000 IU | 5000 IU |
| Mike Fisher. Founder, VitaminDassociation.org [non-profit]. Director of Research, Systems Biology Laboratory, UK. | 4000 IU | 4000 IU |
| Dr. Lina Zgaga, MD, PhD. Associate Professor of Epidemiology, Trinity College Dublin, University of Dublin, Ireland. | 2000 IU | 3000 IU |
| Dr. Irwin Jungreis, PhD, Harvard University. Research Scientist, Massachusetts Institute of Technology, Cambridge, MA, USA. | 2000 IU | 2700 IU |
| Dr. Jane Coad, PhD. Professor of Nutrition, Massey University, New Zealand. | 4000 IU | 2000 IU |
| Dr. Cedric Annweiler, MD PhD. Professor of Geriatric Medicine, School of Medicine, Health Faculty, University of Angers and Department of Medicine, Clinique de l’Anjou, Angers, France. Disclosure: occasional consultant for Mylan Laboratories Inc. | 2000 IU | 2000 IU |
| Dr. Salvatore Minisola, Full Professor of Internal Medicine, « Sapienza » Rome University, Italy. | 4000 IU | |
| Dr. Mats B. Humble, MD PhD. Psychiatrist (retired), Senior lecturer, Department of Medical Sciences, Örebro University, Sweden. | 2000 IU | 3000 IU |
| Dr. Andrea Fabbri, MD PhD. Professor of Endocrinology, Head Endocrinology Division, Ospedale CTO A. Alesini, University of Rome Tor Vergata, Rome, Italy. | 4000 IU | 7000 IU |
| Dr. Steve Jones, PhD FRS. Emeritus Professor of Human Genetics, Dept of Genetics, Evolution and Environment, University College London, UK. | 4000 IU | |
| Dr. Hermann Brenner, MD MPH. Professor of Epidemiology, Head of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany. | 2000 IU | 2000 IU |
| Dr. Helder F. B. Martins, MD PhD (hon).Specialist & Emeritus Professor of Public Health. Former Minister of Health, Mozambique. Former WHO. Member, Mozambican Government COVID-19 advisory committee. | 4000 IU | 4000 IU |
| Dr. G. Siegfried Wedel, MD. Internist-Nephrologist (retired), Vierhöfen, Germany. | 4000 IU | 8000 IU |
| Dr. Robin Weiss, PhD FRCPath FMedSci FRS. Emeritus Professor of Viral Oncology, Division of Infection & Immunity, University College London, UK. | 4000 IU | 2000 IU |
| Dr. Giancarlo Isaia, Full Professor, University of Turini. President of the Academy of Medicine of Turin, Italy. | 2000 IU | |
| Dr. Susanne Bejerot, Professor, Örebro University, Sweden. | 2000 IU | 3000 IU |
| Dr. Antonio D’Avolio, Professor of Pharmacology, University of Turin, Italy. | 4000 IU | 4000 IU |
| Dr. Gustavo Duque, MD PhD FRACP FGSA. Chair of Medicine & Director of the Australian Institute for Musculoskeletal Science (AIMSS). The University of Melbourne and Western Health, Melbourne, Australia. | 2000 IU | 0 IU |
| Dr. Giovanni Passeri, Associate Professor, Internal Medicine, Dep. of Medicine and Surgery, University of Parma, Parma, Italy. | 4000 IU | 4000 IU |
| Dr. Pankaj Kapahi, Professor, Buck Institute for Research on Aging, Novato, California, USA. | 4000 IU | |
| Dr. Giuseppe Poli, Emeritus Professor of General Pathology, University of Turin, Italy. | 2000 IU | 2000 IU |
| Dr. Patrick McCullough, MD. Chief of Medical Services, Summit Behavioral Healthcare, Cincinnati, Ohio USA. | 4000 IU | 50,000 IU |
| Dr. Prashanth Kulkarni, MD DM FSCAI FACC. Consultant Cardiologist, Hyderabad, India. | 4000 IU | 4000 IU |
| Dr. Klaus Badenhoop, MD PhD. Professor, Division of Endocrinology & Diabetes, Department of Internal Medicine, Goethe-University Hospital, Frankfurt am Main, Germany. | 4000 IU | 4000 IU |
| Dr. José-María Sánchez-Puelles, PhD. Senior Researcher, CIB Margarita Salas, CSIC, Spain | 2000 IU | |
| Dr. Carmelinda Ruggiero, MD PhD. Professor of Geriatric Medicine, School of Medicine, University of Perugia, Italy. Head of the Orthogeriatric Unit, S Maria Misericordia Teaching Hospital, Perugia, Italy. Disclosure: Occasional consultant for UCB Pharma. | 4000 IU | 4000 IU |
| Dr. Jose Manuel Quesada Gomez, MD, PHD, Honorary Professor, University of Cordoba. Maimonides Research Institute, Cordoba. Spain. | 2000 IU | Calcifediol266μg/month |
| Dr. Giovanni Minisola, MD. President Emeritus of Italian Society for Rheumatology. Scientific Director of « San Camillo – Forlanini » Foundation, Rome, Italy. | 4000 IU | |
| Christine French, MS. Research Analyst at GrassrootsHealth Nutrient Research Institute [non-profit], Encinitas, CA, USA. | 4000 IU | 5000 IU |
| Dr. Patrizia Presbitero, MD. Clinical and interventional cardiology, Cardio Center, Humanitas Research Hospital Rozzano, Rozzano, Milan, Italy. | 4000 IU | |
| Dr. Ken Redcross, MD. Doctor and on-camera medical expert, New York, USA. Disclosure: scientific advisory board of the Organic & Natural Health Association. | 4000 IU | 10,000 IU |
| Dr. Rajeev Venugopal, MBBS FRCS FACS DM. Consultant Plastic Surgeon/ Associate Lecturer in Surgery, University of the West Indies at Mona, Jamaica. | 2000 IU | 2000 IU |
| Dr. Gianluca Isaia, MD PhD. Geriatrician, Section of Geriatrics, Department of Medical Sciences, University of Turin, A.O.U. Città della Salute e della Scienza di Torino, Molinette, Turin, Italy. | 2000 IU | 2000 IU |
| Dr. Piero Stratta, Professor of Nephrology, University Piemonte Orientale, Italy. | 4000 IU | 4000 IU |
| Dr. Ben Schöttker, PhD. Scientist, Division of Clinical Epidemiology and Ageing Research, German Cancer Research Center, Heidelberg, Germany. | 2000 IU | 1400 IU |
| Dr. Roberto Fantozzi, MD. Full Professor of Pharmacology, University of Turin, Turin, Italy. | 4000 IU | 2000 IU |
| Dr. Sheryl L Bishop, PhD. Professor Emeritus, University of Texas Medical Branch, School of Nursing, Galveston, Texas, USA. | 4000 IU | 2000 IU |
| Dr. Wayne Jonas, MD. Professor of Family Medicine, Georgetown University. Former Director NIH Office of Alternative Medicine, USA. | 2000 IU | |
| Dr. Ferdinando Silveri, Medical Director of the Rheumatology Clinic of the Marche Polytechnic University, Ancona, Italy. | 4000 IU | |
| Dr. Vatsalya Vatsalya, MD. Department of Medicine, University of Louisville. National Institute on Alcohol Abuse and Alcoholism NIH, USA. | 2000 IU | |
| Dr. Rachel Nicoll, PhD. Medical researcher, Umeå University, Sweden. | 4000 IU | 4000 IU |
| Dr. Raimund von Helden, Dr med. Family medicine. Institute VitaminDelta, Lennestadt, Germany. Disclosure: Institute VitaminDelta sells consumer advice including on vitamin D for modest cost, but with no ties to other commercial interests. | 4000 IU | 8000 IU |
| Carole Baggerly, Founder & Director, GrassrootsHealth Nutrient Research Institute [non-profit], Encinitas, CA, USA. | 4000 IU | 10,000 IU |
| Dr. Edward Gorham, PhD MPH. Adjunct Professor, University of California San Diego, School of Medicine, Dept of Family Medicine and Public Health, USA. | 4000 IU | 10,000 IU |
| Dr. David Verhaeghen, MD, Anesthesiology, Algology and Pain Medicine, Aalst, Belgium. | 2000 IU | 3000 IU |
| Dr. Silvia Migliaccio, MD PhD. Associate Professor at University Foro Italico of Roma, Italy. Secretary of the Italian Society of Food Sciences. | 4000 IU | 1000 IU |
| Dr. Vítor Oliveira, MD, Internal Medicine, Brazil. | 4000 IU | 5000 IU |
| Dr. Djamel Deramchi, MD. Functional medicine. GrassrootsHealth Certified Vitamin D*practitioner and Coimbra Protocol Certified Doctor. France. | 4000 IU | 10,000 IU |
| Dr. Wim Soetaert, PhD. Prof. Microbiology & Biotechnology, Ghent University, Centre for Industrial Biotechnology and Biocatalysis (InBio.be), Belgium. | 4000 IU | 5000 IU |
| Dr. Mark S. Braiman, PhD. Professor of Chemistry, Syracuse University, USA. | 4000 IU | 10,000 IU |
| Dr. Mikko Paunio, MD PhD MHS. Adjunct Professor in General Epidemiology, University of Helsinki. Medical Counselor Ministry of Social Affairs and Health, Finland. | 4000 IU | 6000 IU |
| Dr. Manfred Eggersdorfer, PhD. Professor for Healthy Ageing, University Medical Center Groningen, The Netherlands. Member of the Advisory Board of the Johns Hopkins Bloomberg School of Public Health. Disclosure: Head of Nutrition Science and Advocacy, DSM Nutritional Products. Member of the scientific board of PM International. | 2000 IU | 2000 IU |
| Dr. Chris Newton, PhD. Research director, Centre for Immuno-Metabolism, Microbiome and Bio-energetic Research (CIMMBER), UK. | 4000 IU | 4000 IU |
| Dr. Doreen Brodmann, Dr med. Head of Nephrology, Spitalzentrum Oberwallis, Switzerland. | 4000 IU | 10,000 IU |
| Dr. Srijit Mishra, PhD, Economics. Professor, Indira Gandhi Institute of Development Research, Mumbai, India. | 2000 IU | |
| Dr. Marco Infante, MD. Adjunct Professor of Endocrinology, UniCamillus – Saint Camillus International University of Health Sciences, Rome, Italy. | 4000 IU | 4000 IU |
| Dr. Jean-Marc Sabatier, PhD HDR. Director of research at CNRS (French National Centre for Scientific Research), Institut de NeuroPhysiopathologie (INP), Marseille, France. | 4000 IU | 4000 IU |
| Dr. Mohsin Sidat, MD PhD. University Eduardo Mondlane, Mondlane, Mozambique. | 2000 IU | 2000 IU |
| Dr. Dimitrios T. Papadimitriou, MD PhD. Director, Department of Pediatric-Adolescent Endocrinology & Diabetes, Athens Medical Center, Greece. | 4000 IU | 10,000 IU |
| Dr. Bodo Schertel, Dr med. Professor, Hochschule Mannheim, Germany. | 4000 IU | 10,000 IU |
| Dr. Jahit Sacarlal, MD PhD MPH. Professor, Department of Microbiology, Eduardo Mondlane University, Maputo, Mozambique. | 4000 IU | 7500 IU |
| Dr. Espen Haug, Phd. Professor, School of Economics and Business, Norwegian University of Life Sciences (NMBU), Norway. | 4000 IU | 5000 IU |
| Dr. Martin Hewison, PhD. Professor of Molecular Endocrinology, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK. Disclosure: Received honorarium from Thornton Ross (UK) for online seminar. | 2000 IU | 2000 IU |
| Dr. Damien Downing, MBBS MRSB. President, British Society for Ecological Medicine, UK. | 4000 IU | 8000 IU |
| Dr. Linda A. Linday, MD. Assistant Clinical Professor of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA. | 4000 IU | 4000 IU |
| Dr. Rose Anne Kenny, MD FRCP FRCPI FRCPEdin FTCD FESC MRIA. Professor, Chair of Medical Gerontology, Trinity College, Dublin, Ireland. | 2000 IU | 2000 IU |
| Dr. Mihkel Zilmer, Dr. med. Professor, Medical Biochemistry, Head of Department of Biochemistry, Tartu University, Faculty of Medicine, Estonia. | 2000 IU | 2000 IU |
| Dr. Jaan Eha, MD PhD. Professor of Cardiology, Tartu University, Faculty of Medicine, Estonia. | 2000 IU | 2000 IU |
| Dr. Anna Moore, MBBS PgDipNutrMed, London, UK. | 2000 IU | 2000 IU |
| Dr. Roger D. Seheult, MD. Assistant Professor, Loma Linda University School of Medicine. Associate Professor, UC Riverside School of Medicine. Cofounder, MedCram, USA. | 4000 IU | 5000 IU |
| Dr. Jean-Claude Souberbielle, PhD PharmD. Former head of Hormonology Laboratory, Necker Hospital, Paris, France. | 2000 IU | 3300 IU |
| Dr. Emmanuelle Faucon, MD, Toulon, France. Former Medical Affairs Director in Immunology and Virology, Bristol Myers Squibb. | 4000 IU | 4000 IU |
| Dr. Aida Santaolalla, PhD. Senior Data Scientist, Cancer Epidemiology, King’s College London, UK. | 2000 IU | 2000 IU |
| Dr. Elisa Song, MD. Pediatrician, Belmont, CA, USA. | 4000 IU | 5000 IU |
| Dr. Mylene Huynh, MD MPH. Colonel (ret), USAF. Adjunct Assistant Professor, Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, USA. | 2000 IU | 5000 IU |
| Dr. Yosef Weisman, Professor. Retired head of Bone Desease Unit and the Vitamin D Lab, Tel Aviv Souraski Medical Center, Faculty of Medicine, Tel Aviv University, Israel. | 2000 IU | 2000 IU |
| Dr. Andrius Bleizgys, MD PhD. Lector of Clinic of Internal Diseases, Family Medicine and Oncology, Vilnius University Faculty of Medicine, Vilnius, Lithuania. | 4000 IU | 4000 IU |
| Dr. Keshav Singhal, FRCS MS(orth) M.Ch(orth). Professor, Consultant Orthopaedic Surgeon. Chair British Association of Physicians of Indian Origin (BAPIO), Wales. Council Member & Trustee, Swansea University. Fellow of Learned Society of Wales, UK. | 4000 IU | 4000 IU |
| Dr. Gennadi Glinsky, MD PhD. Professor, Institute of Engineering in Medicine, University of California, San Diego, La Jolla, USA. | 4000 IU | 5000 IU |
| Dr. Eero Vasar, MD PhD. Professor of Human Physiology, University of Tartu, Estonia. | 2000 IU | 2000 IU |
| Dr. Frank C. Church, PhD. Professor of Pathology and Laboratory Medicine, University North Carolina School of Medicine, Chapel Hill, NC, USA. | 4000 IU | 5000 IU |
| Dr. Michael J. A. Robb, MD. Physician, Oto-Neurologist, Robb Oto-Neurology Clinic, Phoenix, Arizona. Past President, Association of American Physicians and Surgeons (AAPS), USA. | 4000 IU | 10,000 IU |
| Dr. Giles Duffield, PhD. Associate Professor, Department of Biological Sciences & Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, USA. | 4000 IU | 5000 IU |
| Dr. Harry Wichers, PhD. Professor in Immune Modulation by Food, Wageningen UR, The Netherlands. | 2000 IU | 1000 IU |
| Dr. Matthew A. Nehs, MD. Assistant Professor of Surgery, Harvard Medical School. Program Director, Harvard Combined Endocrine Surgery Fellowship. USA. | 4000 IU | 5000 IU |
| Dr. Hana Fakhoury Hajeer, PhD. Associate Professor of Biochemistry, Alfaisal University, Saudi Arabia. | 2000 IU | 2000 IU |
| Dr. Fatme Al Anouti, PhD Biochemistry. Associate Professor, College of Natural and Health Sciences, Zayed University, UAE. | 4000 IU | 4000 IU |
| Dr. José C. Tutor, PharmD PhD MB. Pharmacology Unit, Health Research Institute, University Clinical Hospital, Santiago de Compostela, Spain. | 4000 IU | 10,000 IU |
| Dr. Wolfgang Schrott, Professor (retired), Chemistry, Hochschule Hof University of Applied Sciences, Germany. | 4000 IU | 2000 IU |
| Dr. Brian Lenzkes, MD, Internal Medicine, San Diego, CA, USA. | 2000 IU | |
| Dr. Hayley A Young, PhD. Associate Professor, Nutrition and Behaviour, Swansea University, UK. | 4000 IU | 4000 IU |
| Dr. Luis Lugones, Assistant Professor Microbiology, Faculty of Sciences, Utrecht University, The Netherlands. | 4000 IU | 5000 IU |
| Beth Ellen DiLuglio, RDN LDN MS in Human Nutrition from Columbia University College of Physicians and Surgeons Institute of Human Nutrition. Former Associate Professor of Nutrition, Palm Beach State College, Lake Worth, FL. Registered Dietitian Nutritionist, Florida, USA. Disclosure: Researcher & writer for OptimalDx.com. | 4000 IU | 4000 IU |
| Dr. David Benton, PhD DSc. Professor, Swansea University, UK. | 4000 IU | 4000 IU |
| Dr. Huub Savelkoul, PhD. Full Professor, Head, Cell Biology and Immunology Group, Wageningen University, The Netherlands. | 2000 IU | 1000 IU |
| Dr. Cicero Galli Coimbra, MD PhD. Assistant Professor of Neurology and Neuroscience, Federal University of São Paulo. President, Institute for Investigation and Treatment of Autoimmunity, Brazil. Creator, « Coimbra Protocol » for autoimmune diseases. | 4000 IU | 20,000 IU |
| Dr. Parag Singhal, MD FRCP FACP. Professor of Medicine, University of South Wales, UK. Consultant Endocrinologist. | 4000 IU | 3300 IU |
| Dr. Meis Moukayed, PhD (Cantab), Professor of Health and Life Sciences, American University in Dubai, Dubai, UAE. | 4000 IU | 10,000 IU |
| Dr. Linda Bluestein, MD. Clinical Assistant Professor, Medical College of Wisconsin, USA. | 4000 IU | 5000 IU |
| Dr. Alex Bäcker, PhD, Biology, Caltech, USA. | 4000 IU | |
| Dr. Chad G. Kahl, MD SFS FAAFP. Clinical Assistant professor of Medicine, Uniformed Services University. Chief Medical Officer, Pentagon Flight Medicine Clinic, USA. | 4000 IU | 5000 IU |
| Dr. Alessandro D. Santin, MD. Professor of Obstetrics & Gynecology, Yale School of Medicine, New Haven, CT, USA. | 4000 IU | 5000 IU |
| Dr. Alessandro Comandone, MD. Director, Dept. of Oncology, San Giovanni Bosco Hospital Turin, Italy. | 2000 IU | |
| Dr. Endrit Shahini, MD MSC FPO-IRCCS. Candiolo Cancer Institute, Candiolo (Torino), Italy. | 4000 IU | |
| Dr. Phillip C. Gioia, MD MPH FAAP FACPM, Certificate in Clinical Informatics. Medical Director of Cayuga County Health Department, NY, USA. | 2000 IU | 800 IU |
| Dr. Edward Jude, MBBS MD FRCP. Professor of Medicine, University of Manchester, UK. | 4000 IU | 3000 IU |
| Dr. Sudeepta Varma, MD DFAPA. Clinical Assistant Professor, Department of Psychiatry, NYU Grossman School of Medicine, NY, USA. | 4000 IU | 4000 IU |
Références
1 The evidence was comprehensively reviewed (188 papers) through mid-June [Benskin ‘20] & more recent publications are increasingly compelling [Merzon et al ‘20; Kaufman et al ‘20; Castillo et al ‘20]. (See also [Jungreis & Kellis ‘20] for deeper analysis of Castillo et al’s RCT results.)
2 E.g.: 20ng/ml: National Academy of Medicine (US, Canada), European Food Safety Authority, Germany, Austria, Switzerland, Nordic Countries, Australia, New Zealand, & consensus of 11 international organizations. 30ng/ml: Endocrine Society, American Geriatrics Soc., & consensus of scientific experts. See also [Bouillon ‘17].
3 [Palacios & Gonzalez ‘14; Cashman et al ‘16; van Schoor & Lips ‘17] Applies to China, India, Europe, US, etc.
4 [Heaney et al ‘15; Veugelers & Ekwaru ‘14]
5 The following include 4000 IU within their tolerable intakes in official guidelines: NAM (US, Canada), SACN (UK), EFSA (Europe), Endocrine Society (international), Nordic countries, The Netherlands, Australia & New Zealand, UAE, and the American Geriatrics Soc. (USA, elderly). No major agency specifies a lower tolerable intake limit. The US NAM said 4000 IU “is likely to pose no risk of adverse health effects to almost all individuals.” See also [Giustina et al ‘20].
