[wpfilebase tag=file id=101 /]Pomegranate (Punica granatum L.) is considered one of the oldest known edible fruits and is the symbolic of abundance and prosperity. For thousand of years, many cultures have believed that pomegranate have beneficiary effects on health, fertility, longevity and rebirth. The recent interest for this fruit is not only because of the pleasant taste, but also due to the scientific evidences that suggest therapeutic activity such as anti-atherogenic, antiparasitic, antimicrobial, antioxidant, anticarcinogenic and antiinflammatory effects. These beneficial effects were attributed to the antioxidative properties of pomegranate phenolic compounds, tannins and anthocyanins as well as other phytochemicals. The constituents of pomegranate have been thoroughly investigated, however, clinical trials are in progress to explore the therapeutic potential of pomegranate products, particularly determining preventive efficacy of pomegranate extracts in cancer, cardiovascular diseases, inflammation, diabetes and ultraviolet radiation-induced skin damage. In order to facilitate the further investigations the information contained in this work is based upon the immense work on impact of administration of pomegranate extracts, particularly in cancer prevention such as skin, prostate, breast, and colon.